This episode podcasts some of the events at the 61st European Renal Association (ERA) held 23-26 May, 2024 in Stockholm, Sweden. We start off by covering the double-blind, international FLOW (Evaluate Renal Function With Semaglutide Once Weekly) trial which was conducted to take on the issue with kidney measures in patients with CKD as a primary outcome.
The FLOW study, conducted in 28 countries, involved 3533 patients recruited between June 2019 and May 2021 who had CKD and type 2 diabetes. Patients were randomized to treatment with semaglutide 1.0 mg once weekly (n = 1767) or placebo (n = 1766), both in addition to standard care. It was stopped early due to a clear positive effect in the intervention arm. Listen to the podcast or read the article to learn more.
Did you know that about 11% of the world’s population has genetic kidney disease? That is 875 million people! While we were in Stockholm at the ERA24 last weekend we also had an opportunity to talk with Prof. John Sayer (University of Newcastle, UK) together with Prof. Roman-Ulrich Müller (University Clinic Cologne, Germany). We talk about how one-third of all renal failure is attributable to faulty genes, such as the deletion of NPHP1, and we also talk about the ethical considerations of sequencing all babies at birth.
Enjoy listening!
LinkedIn profile Prof. John Sayer
LinkedIn profile Prof. Roman-Ulrich Müller
Further reading
- Meet the Experts: Navigating Kidneys and Genes
- FLOW: Semaglutide improves kidney and cardiovascular outcomes in participants with type 2 diabetes and chronic kidney disease
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Table of Contents: ERA 2024
Featured articles
Meet the Experts: Navigating Kidneys and Genes
Chronic Kidney Disease
FLOW-trial: Semaglutide improves kidney and cardiovascular outcomes in type 2 diabetes and chronic kidney disease
Early phase data show albuminuria improvement with avenciguat
Rilparencel leads to kidney function stabilisation in chronic kidney disease and type 2 diabetes
The majority of real-world patients with CKD are not eligible for SGLT2 inhibitor trials
Kidney Transplantation and Dialysis
CD38 inhibition by felzartamab promising for resolution of antibody-mediated rejection following kidney allografts
TATH trial: Twice-weekly haemodialysis can be an alternative to thrice weekly regimen
KIR-HLA class I mismatch could be involved in antibody-mediated rejection of transplanted kidneys
IgA Nephropathy
Atrasentan shows positive interim results in IgA nephropathy: ALIGN phase 3 trial
Zigakibart slows down eGFR decline in IgA nephropathy
Long-term atacicept shows continued benefit in IgA nephropathy
APPLAUSE-IgAN: Iptacopan improves proteinuria in IgA nephropathy
Cardio-Renal Interplay
Semaglutide improves renal outcomes in overweight/obese participants with cardiovascular disease and no diabetes
Discrepancy between cardiovascular RCT participants and real-life CKD patients could limit generalisability of RCT results
MERCURI-1: Perioperative empagliflozin shows renal protection following cardiac surgery
Simulated head-to-head comparison of SGLT-2 inhibitors and GLP-1R agonists in type 2 diabetes
Other Nephrology
Preview of the new KDIGO Guidelines for ADPKD, available later in 2024
APPEAR-C3G: Iptacopan shows promise for complement 3 glomerulopathy
Anti-nephrin autoantibody positivity describes a unique subclass of podocytopathies
Active vitamin D plus low-dose prednisolone is an alternative to high-dose prednisolone in minimal change disease
Claudin-1 is a potential antibody target for crescent glomerulonephritis
Rituximab protocol based on PLA2R1 epitope spreading outperforms the standard GEMRITUX protocol in membranous nephropathy
The REACT score predicts relapse in ANCA-associated vasculitis
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