Home > Haematology > Polygenic risk score could spot people at higher risk for abdominal aortic aneurysm

Polygenic risk score could spot people at higher risk for abdominal aortic aneurysm

Journal
Circulation
Reuters Health - 22/10/2020 - Several genetic risk variants are associated with abdominal aortic aneurysm (AAA), and a polygenic risk score might help identify those who can benefit from screening, according to a genome-wide association study (GWAS). "Our data suggest that extending current screening guidelines to include testing to identify those with high polygenic AAA risk would significantly increase the yield of current screening protocols," Dr. Philip S. Tsao of VA Palo Alto Health Care System, in California, told Reuters Health by email. "In addition, our findings may have implications for future genetically guided therapies to manage progression of AAA." Previous studies have indicated that the heritability of AAA is as high as 70%, but GWASs have identified only 10 loci that are significantly associated with AAA heritability, Dr. Tsao and colleagues note in Circulation. For their study, the team used DNA samples and phenotypic data from 7,642 cases a...


Please login to read the full text of the article.


If you have no account yet, please register now.





Posted on