
I am pleased to introduce this peer-reviewed ASH 2024 Medicom Conference Report. The ASH Annual Meeting, held in San Diego, was again organised as a hybrid meeting, a format that is often used for medical conferences since the COVID pandemic. It is a great event for haematologists to look forward to, as it offers the opportunity to get informed on all aspects of haematology.
The wonderful program covered mostly clinical but also basic and translational topics. We selected several interesting abstracts from this year’s ASH that will most likely change your daily practice now or in the near future. The abstracts are summarised in a way that makes the information easy to digest in a rather short time.
The emerging role of CAR T treatment in a variety of haematological malignancies gets a lot of attention. Further deciphering of the molecular basis of malignant diseases offers more possibilities to stratify patients for treatment options. Many new drugs are discussed in phase 1 and 2 studies. Measurable residual disease becomes an important surrogate endpoint for outcomes across haematological malignancies and helps to inform treatment.
You will find snapshots of all these new developments in this report. I can imagine that these are helpful in your daily practice, and I am certain you will enjoy them.
Gert Ossenkoppele
Biography
Prof. Gert Ossenkoppele was appointed in 2003 as Professor of Haematology at the VU University Medical Center in Amsterdam. He obtained his doctorate of medicine at that same University in 1977. He is board-certified in Haematology and Internal medicine (1984). The title of his PhD thesis (1990) was: “Differentiation induction in acute myeloid leukaemia (AML)”. Gert Ossenkoppele has authored over 480 publications in peer-reviewed journals and is an invited speaker at many national and international scientific meetings. His research interests are mainly translational and include the (stem cell) biology of AML/myelodysplastic syndrome (MDS), leukaemic stem cell target discovery, immunotherapy, and measurable residual disease (MRD) detection using flow cytometry to inform treatment of AML/MDS. He was the PI of national and international clinical trials in myeloid malignancies. He was associate editor of HemaSphere, the official journal of EHA and the European Journal of Haematology and regularly reviewed for many high-standard haematological journals (Blood, Leukemia, JCO, Haematologica, Oncotarget, NEJM). He recently rotated off as chair of the AML working party of HOVON (Dutch-Belgian Hematology Trial Group) and is past vice-chair of the HOVON Executive Board. He rotated off in 2024 as a lead participant of the AML Work package of the European LeukemiaNet (ELN) as well as a board member of the ELN foundation. He is the key opinion leader of WP2 AML of the HARMONY project. He rotated off as a board member of the European Haematology Association (EHA) and was chair of the EHA Educational Committee. He further rotated off as chair of the Global and EU steering committee of the AMLGlobalPortal an educational portal for haematologists (www.amlglobalportal.com).
Recently he retired and now functions as emeritus Professor of Haematology at the Amsterdam University, location VUmc.
In 2022 he received the Jean Bernard Lifetime Achievement Award at the EHA Annual meeting in Vienna.
Recently he stopped most of his professional activities.
Prof. Gert Ossenkoppele has no conflicts of interest to declare.
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Table of Contents: ASH 2024
Featured articles
Meet the Trialist: Prof. Mats Jerkeman on the ALTAMIRA trial
Lymphoma
InMIND: Novel standard-of-care for relapsed or refractory follicular lymphoma?
High CR rates for novel CAR T-cell therapy in follicular lymphoma and DLBCL
Excellent CR rates for venetoclax plus pola-R-CHP in BCL2-positive DLBCL
ATALANTA-1: Promising data for novel CAR T-cell therapy
ZUMA-5: Curative potential of axi-cel in follicular lymphoma
Can we omit auto-SCT in patients with mantle cell lymphoma with undetectable MRD post-induction?
Leukaemia
Quizartinib maintenance therapy crucial for FLT3-ITD-positive AML
Revumenib combination therapy associated with high response rates in relapsed/refractory AML
Venetoclax plus azacitidine in young patients with AML
Promising results for ivosidenib-based triplet therapy in IDH1-mutated malignancies
CPX-351 outperforms FLAG-Ida in AML/MDS and MDS-related mutations
High MRD-negativity rates for venetoclax plus ‘7+3’ chemotherapy in newly diagnosed AML
Findings from phase 3 uproleselan study in AML not all negative
Menin inhibitors on the rise in KMT2Ar acute leukaemia
New standard-of-care for paediatric B-cell ALL
Multiple Myeloma
KCRd offers overall survival benefit over CRd in newly diagnosed MM
AQUILA: Early intervention with daratumumab extends survival in smouldering MM
Emerging mezigdomide-based options for heavily pre-treated MM
IFM2017-03: Daratumumab therapy fruitful for frail patients with MM
CEPHEUS: Further support for daratumumab regimens in untreated MM
Non-Malignant Haematology
Positive trends for etavopivat in sickle cell disease
LUNA 3: Rilzabrutinib meets primary endpoint in ITP
Full-dose or reduced-dose DOACs in high-risk VTE on extended therapy?
Allo-SCT improves lives of children with sickle cell anaemia and abnormal cerebral artery velocities
PIVOT: Can hydroxyurea improve outcomes in haemoglobin sickle cell disease?
Miscellaneous
ANDROMEDA: Daratumumab-based frontline standard-of-care in AL amyloidosis
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