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IBD meds could treat COVID-19

Reuters Health - 02/10/2020 - Immune-response signatures shared by patients with COVID-19 and patients with inflammatory bowel disease (IBD) suggest a possible role for IBD medications in the treatment of COVID-19, researchers report. "A number of overlapping inflammatory pathways between COVID-19 and IBD imply that some of the pre-existing IBD medications, like IL-12/23 inhibitors or TNF inhibitors, could be repurposed for use in COVID-19 patients," Dr. Saurabh Mehandru of Icahn School of Medicine at Mount Sinai, in New York City, told Reuters Health by email. SARS-CoV-2 initiates infection by attaching the receptor-binding domain of the viral spike (S) protein to epithelial angiotensin-converting enzyme-2 (ACE2), which is expressed by intestinal epithelial cells as well as lung epithelial cells. Cleavage of the S protein by transmembrane serine protease 2 (TMPRSS2) then facilitates viral entry into the host cell. Dr. Mehandru and colleagues examined potenti...

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