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Celiac disease tied to increased risk of major osteoporotic fractures

Journal
Osteoporosis International
Reuters Health - 15/09/2020 - Celiac disease is associated with major osteoporotic fracture independent of fracture risk assessment tool (FRAX) score, a Canadian study in Osteoporosis International suggests. For the study, researchers examined data on from the Manitoba Bone Mineral Density Registry to calculate the 10-year risk of major osteoporotic fractures in 693 individuals with celiac disease who were followed for a mean of 7.0 years and 68,037 general population subjects who were followed for a mean of 7.1 years. During the study, the proportion of people in each cohort who experienced one or more major osteoporotic fractures was the same - 8.4% -- even though the celiac disease group was younger, with a greater proportion of men. In the general population, there was good agreement between FRAX predicted and observed 10-year major osteoporotic fracture probability. In patients with celiac disease, however, predicted and observed fracture probabilities d...


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