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Children with AD: high risk of bacterial infections in carriers of a filaggrin gene variant

Presented By
Prof. Alina Suru , Carol Davila University of Medicine and Pharmacy, Romania
Conference
SPIN 2022
Doi
https://doi.org/10.55788/470a2525
Superinfections are the most common complications in atopic dermatitis (AD). When lesions become excoriated, they act as a gateway for the entry of infectious agents. Furthermore, a disruption of the normal skin microbiome contributes to infections. As Prof. Alina Suru (Carol Davila University of Medicine and Pharmacy, Romania) pointed out, patients with AD have an increased risk of infection due to defects in the skin and further cutaneous innate and adaptive immune abnormalities with type-2 inflammation. Staphylococcus aureus colonisation and cutaneous dysbiosis are additional factors that leave AD patients prone to infections [1]. AD-associated skin infections can progress to systemic complications such as sepsis, endocarditis, and septic arthritis. Whereas infectious complications must be treated with antibiotics, it is controversial whether to use antibiotics simply in exacerbations of AD [2]. Up to 90% of patients with AD are coloni...


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