Home > Dermatology > SPIN 2022 > New Treatment Options in Alopecia Areata > Alopecia areata pathogenesis: known genetic background, unknown environmental triggers

Alopecia areata pathogenesis: known genetic background, unknown environmental triggers

Presented By
Prof. Rodney Sinclair , University of Melbourne, Australia
Conference
SPIN 2022
Doi
https://doi.org/10.55788/1407d353
Alopecia areata (AA) is a polygenic and multifactorial autoimmune disease that results in non-scarring hair loss. Both local and systemic environmental factors can trigger the disease. As Prof. Rodney Sinclair (University of Melbourne, Australia) pointed out, AA is a multifactorial disease with a known genetic background and unknown environmental triggers [1]. Both innate and acquired immunity are involved in the pathogenesis of AA. In a genome-wide association study, 139 single nucleotide polymorphisms could be identified that are significantly associated with AA [2]. Unknown environmental triggers can be divided into local and systemic factors. Local factors are a loss of hair follicle immune privilege causing inflammatory cells to swarm and attack the hair bulb in what is known as the “swarm of bees”. Both intrafollicular CD8 cells and multiple cytokines and chemokines are involved in this process. Systemic factors that might trigger AA are increased se...


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