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Gene expression different in allergic, irritant contact dermatitis

Reuters Health - 01/01/2021 - Artificial intelligence (AI) can help identify biomarkers to distinguish between contact dermatitis (CD) due to allergic reactions or to irritants, according to new findings. There were major differences in gene expression between the two CD types, Dr. Nanna Fyhrquist of Karolinska Institutet in Stockholm and colleagues found. "The identified biomarkers represent key features of skin inflammation and repair, which might - in addition to serving as biomarkers for diagnostic purposes - prove to be efficient indicators of disease risk or improvement," they write in the Proceedings of the National Academy of Sciences. CD accounts for more than 90% of occupational skin disorders, and includes allergic CD (ACD) and irritant contact dermatitis (ICD), the authors explain. ACD involves hypersensitivity to sensitizing agents, while ICD results from skin damage caused by irritants. The two entities are difficult to distinguish from o...

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