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Fern extract reverses UV induced cell damage and occurrence of new lesions

Presented By
Dr Stefania Guida, La Sapienza University, Rome
Conference
EADV 2022
In a retrospective Italian trial including patients with severe actinic keratosis (AK), local and oral preparation of polypodium leucotomos extract led to clinical reversal of AK lesions at 12 months, assessed via reflectance confocal microscopy. The extract ameliorated all assessed skin parameters, amongst others honeycomb pattern, reticulated collagen, and mottled pigmentation Extracts of the South American fern Polypodium leucotomos (PLE) are a common ingredient in sun creams. The agent has immunomodulatory effects, can prevent DNA damage, and has been shown to boost innate DNA repair systems, which makes it an interesting candidate for treating actinic keratoses. But is topically and orally PLE able to reverse severe actinic damage? To answer this question, a study including 131 patients with severe signs of photoaging and at least 3 AKs lesions was performed [1]. Patients were randomised into 3 treatment groups. The first received topical photo...


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