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Moderate-to-severe CKD tied to worse VTE outcomes

JAMA Network Open
Reuters Health - 09/11/2020 - A registry study of patients with venous thromboembolism (VTE) suggests moderate-to-severe chronic kidney disease (CKD) is associated with greater risks of death, VTE recurrence and major bleeding compared to mild or no CKD. "There is plenty of room to improve the outcomes of VTE patients with CKD," Dr. Shinya Goto of Tokai University School of Medicine in Kanagawa told Reuters Health by email. He highlighted that "patients with moderate/severe CKD patients are less likely to be treated with direct-acting oral anticoagulants (DOACs), but noted that "appropriate dosing of DOACs in CKD patients is difficult because the drugs are excreted, at least in part, by the kidney." As reported in JAMA Network Open, Dr. Goto and colleagues studied outcomes of close to 9,000 VTE patients (median age, 57; 49% women; 77% White). Overall, 2,055 (23%; median age, 70) had moderate-to-severe CKD. Fifty-seven percent of those with moderate-to-severe ...

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