
Thank you for your interest in this edition of Medicom’s Conference Report covering the European Society of Cardiology Heart Failure Association Congress for 2025, held in Belgrade, Serbia. This year’s exciting meeting covered a wide array of topics including novel data on gene therapies, new data on innovative devices, additional analyses elucidating effects of finerenone, and data from wide range studies of specific populations including patients with HCM and patients with amyloid. In the following pages you will see summaries covering a broad range of cutting-edge science including phase 1 trials, sub studies of large outcomes trials, observational research, and implementation science. You will also see an exciting look forward at future trials in heart failure.
I hope you find the summaries included informative, balanced, and inspiring as we look forward to great promise in the scientific innovation that will improve outcomes for patients suffering from heart failure. Thank you for your interest in our conference report.
Sincerely,
Prof. Marc Bonaca
Biography
Marc P. Bonaca, MD, MPH, is a Cardiologist and Vascular Medicine Specialist who serves as the Executive Director of CPC Clinical Research and CPC Community Health at the University of Colorado Anschutz Medical Campus. He is the Director of Vascular Research and a Professor of Medicine at the University of Colorado School of Medicine and the inaugural holder of the William R. Hiatt Endowed Chair in Cardiovascular Research.
Dr Bonaca earned his medical degree from the University of Connecticut School of Medicine and his Masters in Public Health at Harvard University. He served as a Medical House Officer at Brigham and Women’s Hospital and Harvard Medical School. After completion of his training, he joined the faculty of the Cardiovascular Division and Vascular Medicine section of Brigham and Women’s Hospital and Harvard Medical School and became an Investigator at the TIMI Study Group.
Dr Bonaca’s research focus is on ischemic risk in patients with atherosclerotic vascular disease, risk prediction, and risk modification through the use of pharmacologic and biologic therapies. His key areas of interest include patients with peripheral artery disease, polyvascular disease and diabetes with a focus on the breadth of risk including ischemic limb outcomes, microvascular complications and major adverse cardiovascular events.
Conflict of Interest Statement:
Dr Bonaca is the Executive Director of CPC, a non-profit academic research organization affiliated with the University of Colorado, that receives or has received research grant/consulting funding between August 2021 and present from: Abbott Laboratories, Agios Pharmaceuticals, Inc., Alexion Pharma, Alnylam Pharmaceuticals, Inc., Amgen Inc., Angionetics, Inc., Anthos Therapeutics, ARCA Biopharma, Inc., Array BioPharma, Inc., AstraZeneca and Affiliates, Atentiv LLC, Audentes Therapeutics, Inc., Bayer and Affiliates, Beth Israel Deaconess Medical Center, Better Therapeutics, Inc., Boston Clinical Research Institute, Bristol-Meyers Squibb Company, Cambrian Biopharma, Inc., Cardiol Therapeutics Inc., CellResearch Corp., Cleerly Inc., Cook Regentec LLC, CSL Behring LLC, Eidos Therapeutics, Inc., EP Trading Co. Ltd., EPG Communication Holdings Ltd., Epizon Pharma, Inc., Esperion Therapeutics, Inc., Everly Well, Inc., Exicon Consulting Pvt. Ltd., Faraday Pharmaceuticals, Inc., Foresee Pharmaceuticals Co. Ltd., Fortress Biotech, Inc., HDL Therapeutics Inc., HeartFlow Inc., Hummingbird Bioscience, Insmed Inc., Ionis Pharmaceuticals, IQVIA Inc., Janssen and Affiliates, Kowa Research Institute, Inc., Kyushu University, Lexicon Pharmaceuticals, Inc., Medimmune Ltd., Medpace, Merck & Affiliates, Nectero Medical Inc., Novartis Pharmaceuticals Corp., Novo Nordisk, Inc., Osiris Therapeutics Inc., Pfizer Inc., PhaseBio Pharmaceuticals, Inc., PPD Development, LP, Prairie Education and Research Cooperative, Prothena Biosciences Limited, Regeneron Pharmaceuticals, Inc., Regio Biosciences, Inc., Saint Luke’s Hospital of Kansas City, Sanifit Therapeutics S.A., Sanofi-Aventis Groupe, Silence Therapeutics PLC, Smith & Nephew plc, Stanford Center for Clinical Research, Stealth BioTherapeutics Inc., State of Colorado CCPD Grant, The Brigham & Women's Hospital, Inc., The Feinstein Institutes for Medical Research, Thrombosis Research Institute, University of Colorado, University of Pittsburgh, VarmX, Virta Health Corporation, Worldwide Clinical Trials Inc., WraSer, LLC, and Yale Cardiovascular Research Group.
Dr. Bonaca receives support from the AHA SFRN under award numbers 18SFRN3390085 (BWH-DH SFRN Center) and 18SFRN33960262 (BWH-DH Clinical Project).
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Table of Contents: HFA 2025
Featured articles
FINEARTS-HF confirms: analysis suggests premature cessation of Finerenone is associated with risk and supports long-term treatment
Innovative Devices
FUTURE-HF: Novel IVC sensor may help control volume and improve function outcomes
C-MIC II: Cardiac microcurrent therapy in HFrEF
Updates on Finerenone
Real-world eligibility for finerenone: insights from the FIDELITY pooled analysis
FINEARTS-HF confirms: analysis suggests premature cessation of Finerenone is associated with risk and supports long-term treatment
FIVE-STAR: Mechanistic effects of finerenone in T2D plus CKD unravelled
New Therapies for Hypertrophic Cardiomyopathy
SEQUOIA-HCM: Aficamten effects consistent across regions
Large Trials, Big Impact
PRAISE-HFrEF: Is it safe to use GLP1-receptor agonists in clinically severe HF?
HELIOS-B: Health benefits of vutrisiran for ATTR-CM may increase over time
EMPEROR-Preserved: Diastolic dysfunction might predict response to empagliflozin
GALACTIC-HF: zooming in on efficacy data and subgroups
More Hot Trials from HFA
PREFER-HF: Is iron therapy helpful in HFpEF with iron deficiency?
SOGALDI-PEF: SGLT2 inhibitor plus MRA improves biomarker outcomes in HFp/mrEF
REDICAE: Diuretic withdrawal appears feasible in stable HFrEF
GLADIATOR: Anti-ulcer agent geranylgeranylacetone explored in HFpEF
High vs low positive end-expiratory pressure in IMV may impact survival
Gene Therapy and the Future of HF Management
Artificial intelligence in HF management
Consistent results for nexiguran ziclumeran across wildtype and variant ATTR-CM
New gene therapy for HFrEF passes phase 1 testing
MUSIC-HFpEF: Encouraging early results of novel gene therapy for HFpEF
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