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Even low doses of steroids tied to higher heart-disease risk

PLoS Medicine
Reuters Health - 03/12/2020  -Even low doses of steroids are associated with a higher risk of cardiovascular disease (CVD), according to a large observational study from the U.K. "The findings of our study highlight the importance of treating patients with the minimal effective dose of steroids for the shortest duration of time, while appropriately, promptly and regularly monitoring cardiovascular risk," Dr. Mar Pujades-Rodriguez of the University of Leeds told Reuters Health by email. "Implementing and evaluating targeted intensive cardiovascular-risk-factor-modification interventions, beyond diagnosis of inflammatory arthropathies and systemic lupus erythematosus, even when prescribing low glucocorticoid doses, is essential," she added. To quantify glucocorticoid dose-dependent CV risk, the researchers analyzed the medical records of more than 87,000 adults with common immune-mediated inflammatory diseases and no prior CVD. Their mean age was 56 years and 3...

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