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BOXing out oxygen and blood pressure targets

Presented By
Prof. Jacob Eifer Møller & Dr Jesper Kjaergaard, Copenhagen University Rigshospitalet, Denmark
ESC 2022
In dual back-to-back presentations from the 2-by-2 factorial BOX trial, both of which were simultaneously published in the New England Journal of Medicine, researchers conclusively showed that outcomes of comatose patients after an out-of-hospital cardiac arrest (OHCA) are not affected by shifting targets of oxygenation or blood-pressure. BOX (NCT03141099) enrolled 789 comatose patients who had been admitted to hospital after resuscitated cardiac arrest and had a sustained return to spontaneous circulation [1–4]. All participants received temperature control at 36°C with mechanical ventilation for at least 24 hours, prior to return to normothermia. BOX was a double-blind, randomised trial with a 2-by-2 factorial design, in which the researchers evaluated a mean arterial blood-pressure target of 63 mmHg as compared with 77 mmHg; patients were also assig...

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