Home > Cardiology > ESC 2022 > ARBs + beta-blockers may delay Marfan syndrome aortic root replacement

ARBs + beta-blockers may delay Marfan syndrome aortic root replacement

Presented By
Dr Alex Pitcher, Oxford University Hospitals NHS Foundation Trust, UK
ESC 2022
A meta-analysis on the effects of angiotensin receptor blockers (ARBs) and beta-blockers in >1,400 Marfan syndrome patients has concluded that both drugs have similar, substantial, and independent effects on reducing aortic root size in these patients. The authors suggest that, if maintained over a period of several years, combination therapy may delay the need for elective aortic root surgery in patients with Marfan syndrome. The connective tissue disorder Marfan syndrome is associated with characteristic aortic root enlargement, which increases the risk of life-threatening aortic dissection and rupture, sometimes in early adulthood. Elective surgery to replace the aortic root is often discussed with the patient when the aortic root reaches 4.5–5 cm. Limited previous data has led to the recommendation of using beta-blockers to retard aortic growth. However, some clinical evidence also suggests that ARBs might slow aortic root growth in Marfan syndrome....

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