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Edoxaban non-inferior to vitamin K antagonist in TAVI patients

Presented By
Prof. George Dangas, Mount Sinai Hospital, USA
ESC 2021
Anticoagulation strategies for atrial fibrillation (AF) with either edoxaban or vitamin K antagonists (VKA) were evaluated in patients post transcatheter aortic valve implantation (TAVI) in the ENVISAGE-TAVI AF trial. Edoxaban demonstrated non-inferiority in Net Adverse Clinical Events (NACE); however, due to a higher rate of major bleeding, there was no non-inferiority in the safety outcome [1]. ENVISAGE-TAVI AF (NCT02943785) is a prospective randomised, open-label, blinded trial comparing edoxaban to VKA in AF patients with indication for chronic anticoagulation therapy after TAVI. The primary efficacy outcome was defined as NACE, comprising components such as all-cause death, myocardial infarction, or ischaemic stroke. An additional primary safety outcome was major bleeding as defined by the International Society on Thrombosis and Haemostasis (I...

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