https://doi.org/10.55788/466ac1c2
Prof. Xavier Jouven (Georges-Pompidou European Hospital, France) and co-authors aimed to develop a sudden cardiac death prediction with a particular focus on the low-risk general population since they comprise the highest absolute number of sudden cardiac death and are more difficult to capture than patients with known high-risk factors, such as previous myocardial infarctions [1]. The study group included 12,784 cases of sudden cardiac death from the Paris Sudden Death Expertise Center and 10,000 matched controls. Using AI, an individualised 1-year predicted risk score for sudden cardiac death was calculated.
Selected were 200 variables from 10,000 medical codes. The developed deep-learning model displayed an area under the curve (AUC) of 0.88, a sensitivity of 81%, and a positive predictive value of 88%. Notably, when non-cardiovascular variables were added, the AUC of the model was elevated from 0.81 to 0.88. Furthermore, the model was able to identify participants who had a risk of 90% or more of experiencing sudden cardiac death in the coming year with a positive predictive value of 95%, capturing 43% of the total number of sudden cardiac death cases. The study group will be working to improve the sudden cardiac death risk prediction model by identifying clinical subgroups of interest in a successive study.
- Jouven X, et al. Prediction of sudden cardiac death using artificial intelligence. Late-breaking science 1, EHRA 2022, 3–5 April, Copenhagen, Denmark.
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Table of Contents: EHRA 2022
Featured articles
Letter from the Editor
Diagnostics and Prevention
Cardiac magnetic resonance imaging improves prediction of post-MI sudden cardiac death
AI model accurately predicts sudden cardiac death in overall population
AI model accurately discriminates between arrhythmias
Impact of AF screening on stroke prevention influenced by systolic blood pressure
Developments in Devices
Conduction system pacing potential alternative for biventricular pacing in heart failure
Left bundle branch area pacing is a feasible technique for HF and bradyarrhythmia
Focus on the efficacy of cardiac resynchronisation therapy in HF plus concomitant AF
RESET: No survival benefit of CRT-defibrillator over CRT-pacemaker in heart failure
Insertable cardiac monitors effective for AF detection in cryptogenic stroke
Updates on Ablation
First results of the POWER FAST III trial
Real-world safety results on pulsed-field ablation with pentaspline catheter
VANISH: Ablation reduces shock burden compared with anti-arrhythmic drug in ventricular tachycardia
Low AF recurrence rates after PVI using pulsed-field ablation
Pulsed-field ablation reduces neurocardiac damage versus cryoballoon ablation
Ultrasound-guided femoral venipuncture reduces complications in catheter ablation
News on Atrial Fibrillation
Sex differences revealed in AF determinants and AF progression
Early rhythm-control therapy efficacious in men and women with AF
Progression in remote app-based monitoring of atrial fibrillation
Other Topics
Benefits of SGLT2 inhibitors may extend beyond HF-associated outcomes
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