Home > Cardiology > Causal link between haematopoietic loss of Y chromosome and cardiac disease unravelled

Causal link between haematopoietic loss of Y chromosome and cardiac disease unravelled

Expert
Dr Soichi Sano, University of Virginia School of Medicine, Charlottesville, VA
Journal
Science
A study by Dr Soichi Sano (University of Virginia School of Medicine, Charlottesville, VA) and colleagues, published in the journal Science, demonstrated that male mice, genetically modified so that their bone marrow cells lacked the Y chromosome, had an increased risk of mortality and age-related profibrotic diseases, such as reduced cardiac function [1]. The results were validated in human males, suggesting that mosaic loss of Y chromosome (mLOY) in haematopoietic cells is causally related to cardiac dysfunction. The investigators reconstituted the bone marrow of mice with cells lacking the Y chromosome to model the process of haematopoietic mLOY. This process often occurs with age and has been associated with a variety of medical conditions. However, the causal link between the one and the other had yet to be demonstrated. The research team reported increased mortality, fibrosis, and cardiac dysfunction in the mice with mLOY in haematopo...


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