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UV-induced mutations in seemingly normal skin may predict skin cancer

Journal
Science Advances
Reuters Health - 11/01/2021 - A novel technique called ultradeep sequencing revealed clonal mutations (CMs) induced by ultraviolet (UV) light exposure in seemingly normal skin samples. Researchers say the findings could pave the way to assessing skin damage and skin cancer risk before any signs emerge. "Our study not only confirmed the existence of microscopic groups of cells in the normal skin with DNA alterations, so-called 'mutations,' but also allowed us to discover systematic differences between the mutations caused by UV from the ones caused by aging or other environmental factors," Dr. Gyorgy Paragh and Dr. Lei Wei, both of Roswell Park Comprehensive Cancer Center in Buffalo, New York, told Reuters Health by email. "The UV-induced mutations often occur in specific sites ('hotspots') of human genes," they said, "and interestingly, some of these sites are rarely mutated in non-sun-exposed skin even with aging or other factors." "We knew that mutational h...


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