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Proton pump inhibitor use tied to childhood asthma

JAMA Pediatrics
Reuters Health - 08/02/2021 -  Children who use proton pump inhibitors (PPIs) may be at increased risk of developing asthma, a Swedish study suggests. Researchers examined registry data on children and adolescents up to 17 years old who were matched 1:1 into 80,870 pairs including one youth who used PPIs and one of similar age and propensity score who didn't use PPIs. After a median follow-up of 3.0 years, youth who used PPIs were significantly more likely to be diagnosed with asthma (hazard ratio 1.57). "This potential association has been reported in a few previous observational studies of PPI exposure in pregnancy and infancy," said lead study author Yun-Han Wang of the Karolinska Institute in Stockholm. "One hypothesized underlying mechanism linking PPIs to asthma is that PPIs may alter gut and lung microbiomes through inhibition of gastric acid secretion, subsequently leading to asthma through immune dysregulation," Wang said by email. However, it...

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