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Proteome abnormalities improve prediction of RA development

Presented By
Dr Liam O´Neil, University of Manitoba, Canada
ACR 2019
Results from a late-breaking study showed that abnormalities in the proteome are a valuable biomarker to predict the development of rheumatoid arthritis (RA), in addition to elevated anti-citrullinated protein antibodies (ACPA). Although individuals with elevated ACPA have a higher risk to develop RA, most will not do so. Therefore, an additional biomarker for the prediction of RA is urgently needed. Dr Liam O´Neil (University of Manitoba, Canada) evaluated whether abnormalities in the serum proteome may allow for a better prediction of future disease onset. Using SOMAscan array, quantitative levels of 1,307 proteins were determined in serum samples from 17 first-degree relatives of RA patients who developed inflammatory arthritis synovitis after having been followed prospectively for a mean of 3.2 years. All 17 subjects were ACPA+ at time of inflammatory arthritis diagnosis. In each individual, 2 samples were assessed: 1 at the time of inflammatory arthri...

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