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Lowering LDL cholesterol in older patients is beneficial

Presented By
Dr Baris Gencer, Brigham and Women’s Hospital, USA
AHA 2020
  In patients aged ≥75 years, lipid-lowering therapy was as effective in reducing cardiovascular events as it was in patients <75 years. A 26% reduction was seen in major events per 1 mmol/L reduction of low-density lipoprotein (LDL) cholesterol. These results from a systematic review and meta-analysis should strengthen guideline recommendations for the use of lipid-lowering therapies in older patients [1]. Dr Baris Gencer (Brigham and Women’s Hospital, USA) presented a systematic review and meta-analysis, which included 24 trials from the Cholesterol Treatment Trialists’ Collaboration meta-analysis, as well as 5 randomised controlled cardiovascular outcome trials, all recently published (2015–2020). The results were simultaneously published in The Lancet [2]. In total, the analysis included 244,090 patients, 21,492 (8.8%) of whom were aged ≥75 years. Of those, 11,750 (54.7%) were from statin trials, 6,209 (28.9%) fro...

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