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Bioactives produced by gut bacteria to modulate immune response

Presented By
R. Giri, University of Queensland, Australia
ECCO 2020
An anaerobic culturing and NF-κB reporter assay system allowed for the rapid identification of bacteria producing immunomodulatory bioactives. The investigators think this may lead to the development of novel therapeutics [1]. NF-κB is a protein complex that controls transcription of DNA, cytokine production, and cell survival. In the study, the NF-κB suppressive effects of culture supernatants from 23 different isolates were tested on colonic epithelial cell lines. Suppressive culture supernatants were also tested on human-derived colonic organoids from inflammatory bowel disease (IBD) patients and healthy controls, and IL-8 expression was measured. Furthermore, culture supernatants from one specific NF-κB-suppressive Clostridium strain (AHG0001) was also tested in a spontaneous colitis mouse model in vivo. Culture supernatants from 5 of 23 screened isolates significantly suppressed NF-κB activation. The selected...

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