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New formulation of rimegepant: fast onset of action

Conference
AAN 2019
The calcitonin gene-related peptide receptor antagonist rimegepant had already demonstrated efficacy in acute migraine. An orally dissolving tablet (ODT) formulation with a more rapid onset of action compared with the previously studied tablet was tested in a multicentre phase 3 trial. A single dose of rimegepant ODT demonstrated rapid and sustained clinical benefits within 60 minutes and through 48 hours post-dose [1]. Tolerability was comparable to placebo, including liver function tests. This so-called Study 303 randomised 1,375 subjects to rimegepant 75 mg ODT or placebo, with which they treated 1 migraine attack of moderate or severe pain intensity. The coprimary endpoints were freedom of pain after 2 hours, and freedom from the most bothersome symptom. A total of 1,351 subjects were evaluated for efficacy. Rimegepant ODT was superior to placebo for 2-hour pain freedom (21.2% vs 10.9%; P<0.0001) and freedom from the most bothersome symptom (35.1% v...


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