Granulomatous rosacea: exploratory histological markers

In an initial histological profiling comparing granulomatous rosacea (GR) biopsies to erythematotelangiectatic rosacea (ETR) biopsies and to healthy controls, Dr EunHye Hong (Hallym University Sacred Heart Hospital, Korea) presented her data identifying that elevated numbers of mast cells and higher expression of toll-like receptor 2 (TLR2) are distinct to GR [1]. GR is a unique disease variant of rosacea, characterised by chronic relapsing inflammatory disease with various clinical features such as facial erythema, papules, flushing, pustules, and telangiectasias. Histopathologic findings feature characteristic non-caseated epithelioid granulomas. Little is known about the cell types involved in propagating GR or the underlying signalling that drives this disease. Neurovascular/neuroimmune dysregulation, which includes both anatomic and physiochemical differences present in rosacea-prone skin as compared with healthy facial skin, appears to be a major con...

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Posted on 21 June, 201924 March, 2021