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Bladder cancer in young patients

Presented By
Dr Roland Seiler, Prof. Morgan Rouprêt, Prof. Fiona Burkhard
EAU 2019
IMvigor 210
Dr Roland Seiler (Inselspital University Hospital of Bern, Switzerland) showed that bladder cancer morphology appears to be different in younger patients, with urothelial carcinoma being rarely observed in paediatric patients, whereas clear cell adenocarcinoma, leiomyosarcoma, and rhabdomyosarcoma are more common. The underlying hypothesis is that there are molecular aspects of bladder cancer that are unique to younger patients. Dr Seiler explained, “We do tend to see clusters of bladder cancer in some families, but it can be difficult to discern if these are due to shared risk factors, such as environmental exposures or lifestyle choices (i.e. tobacco use), or if these are due to germline mutations within the family.” Importantly, there are currently no guidelines about when to refer younger patients with bladder cancer to genetic counselling. Other malignancies, however, have tackled this unmet need [1], and Dr Seiler pointed out that for the time...

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