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New Versions of Botulinum Toxins

Presented By
Prof. Cynthia Comella, Rush University Medical Center, USA
Several serotypes of botulinum toxins (A1, A2, A3, B, C1, D, E, F, and G) exist. Currently available versions of botulinum toxins are serotype A (e.g. onabotulinum toxin A, abobotulinum toxin A, and incobotulinum toxin A) and serotype B (e.g. rimabotulinum toxin B). Prof. Cynthia Comella (Rush University Medical Center, USA) focused on new versions of botulinum toxin. She started by briefly mentioning an innovative botulinum topical gel (RT001), a substance that first appeared promising in phase 1 and 2 studies, but which failed to meet clinical endpoints during phase 3 clinical trials. The development plan for RT001 was discontinued and it was decided to focus on the injectable botulinum toxin A version RT002. Agents with a prolonged effect in chronic conditions, fewer injection series over time, a reduced waning effect between injections, and improved patient satisfaction might provide a prolonged optimal benefit. A safety and tolerability study in cervi...

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