Home > Neurology > TOXINS 2019 > Parkinson > Sialorrhea


Presented By
Prof. Wolfgang Jost, Parkinson-Klinik Ortenau, Germany
Phase 3, SIAXI
In his presentation, Prof. Wolfgang Jost (Parkinson-Klinik Ortenau, Germany) discussed approved and unapproved uses of botulinum neurotoxins. He showed ways to manage intractable sialorrhea, a troublesome and disabling symptom associated with various neurological conditions. Every adult produces up to 1.5 litres of saliva per day by the sublingual, the parotid (1/4-1/3, serous), but mainly by the submandibular gland (≥2/3, mucous and serous), according to Prof. Jost. While sialorrhea refers to excessive saliva production, drooling means unintentional loss of saliva from the mouth, he explained. Common causes of sialorrhea are Parkinson's disease, stroke, amyotrophic lateral sclerosis, traumatic brain injury, or cerebral palsy. Consequences of sialorrhea may be of a social or medical nature. Embarrassment, social isolation, stigmatisation, perioral skin breakdown, pneumonia due to aspiration of saliva, choking, and dehydration, all may lead to increa...

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